concentration-effect relationship of intrapritoneal administration of 1, 25 (oh) 2-vitamin d in a chronic constriction model of neuropathic pain
نویسندگان
چکیده
introduction: results: these findings revealed the exaggerated responses in the group which received cci. the group which was treated by 1 μg/kg of 1,25 vit d3 showed a significant reduction in pain behavior. injection of 1,25 vit d3 did not change the response of animals to the acetone drop and von frey filament. discussion: our results showed that antinoceptive effect of 1,25 vit d3 in a rodent neuropathic pain model is dose dependent and this vitamin may provide new approach for treatment of chronic pain.the presence of nuclear receptors of 1,25 dihydroxy vitamin d3 (1,25 vit d3), the biologically active metabolite of vitamin d, in neurons and glial cells indicates the biological effect of this vitamin in the nervous system. the present experiment was conducted to identify the effects of different doses of 1,25 vit d3 on mechanical and cold allodynia in rodent model of neuropatinc pain. methods: a mononeuropathy was produced by chronic constrictive injury (cci) of the sciatic nerve. 1,25 vit d3 (0.3, 0.6 ,1 μg/kg) was administered by an i.p. injection every 2 days during a month after cci. mechanical and cold allodynia were evaluated by von frey filament and acetone respectively.
منابع مشابه
Concentration-Effect Relationship of Intrapritoneal Administration of 1, 25 (OH) 2-Vitamin D in a Chronic Constriction Model of Neuropathic Pain
Introduction: Results: These findings revealed the exaggerated responses in the group which received CCI. The group which was treated by 1 μg/kg of 1,25 vit D3 showed a significant reduction in pain behavior. Injection of 1,25 vit D3 did not change the response of animals to the acetone drop and von frey filament. Discussion: Our results showed that antinoceptive effect of 1,25 vit D3 in a rod...
متن کاملEffects of co-administration of chronic curcumin and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, curcumin and exercise can be effective treatments for alleviating sensory neuropathic pain individually. Now the combined effect of chronic curcumin (Cur) and forced exercise on behavioral pain responses in the neuropathic pain model of chronic const...
متن کاملP59: Effect of Umbelliprenin on Behavioral Responses of Neuropathic Pain and the Expression of Inflammatory Factors in Chronic Constriction Injury Model of Neuropathic Pain in Male Rats
Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...
متن کاملEffects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, physical activity or progesterone can be an effective treatment for alleviating sensory neuropathic pain individually. In this way, the combined effect of chronic progesterone and forced exercise on behavioral pain responses in the neuropathic pain m...
متن کاملEffect of 1/25 (OH)2-Vitamine D on Bone Mineral Density in Childhood Acute Leukemia
Abstract Background Bone mineral density (BMD) may have occurred following treatment of Acute lymphoblastic Leukemia (ALL). 25-hydroxyvitamin D has been insufficiency described in these patients. In this Randomized Control Trial (RCT), we assessed the effectiveness of oral vitamin D administration after one year of treatment to protect bone density. Materials and Methods Twenty-four survivo...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
basic and clinical neuroscienceجلد ۲، شماره ۳، صفحات ۴۳-۵۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023